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Conduct large-scale nationwide cancer prevention studies

Cancer Prevention Study-3 (CPS-3)

Studies have shown that being physically active decreases one’s risk of various cancers, but much more remains to be learned. At CPS-3 Enrollment and on Follow-Up Surveys, CPS-3 participants are asked questions related to different types of physical activity, sedentary behavior, and sleep. These survey questions are designed to measure typical participant behaviors.

In the Accelerometry Sub-Study, we will collect objectively measured activity data using a device called an activity monitor on 20,000 CPS-3 participants who will be randomly selected and invited to participate. Participants will wear this device around their waist for 7-days while awake. Using this information, we will be able to study patterns of physical activity and sitting time in a more detailed way to better understand how physical activity and sitting time affect health and advance public health recommendations for cancer and other disease prevention.


American Cancer Society staff researchers are continually developing innovative ways to enhance CPS-3 data collection and making it easier for our dedicated participants to engage with CPS-3. One exciting opportunity that we're testing in Summer 2020 is a participant portal.

The goals for the portal include:

  • ● Allowing efficient and safe two-way communication between study participants and the research team.
  • ● Enhancing the CPS-3 experience for participants by making it easier to complete surveys and share other types of information.
  • ● Accelerating scientific discovery by collecting study-related data more efficiently.
  • ● Investigating and testing novel data collection methods.
  • ● Saving money by reducing/minimizing our reliance on traditional paper surveys so that we can use those funds for even more lifesaving research.

A small randomly selected group of CPS-3 participants will be invited via email to join and use the test version of the portal before it’s available to all participants. Their feedback will help guide us to build a CPS-3 portal that enhances our data-collection tools and that's also convenient, easy to use, and appealing. It will be another strong player in our collection of efforts to lead the fight for a world without cancer.


Since the 1950s, more than 2.5 million dedicated study participants have joined the Cancer Prevention Studies, and their commitment to these vital research efforts has helped us better understand what causes cancer so that we can ultimately prevent it.

In December 2013, the American Cancer Society completed the initial recruitment of its newest study, Cancer Prevention Study-3, with over 304,000 participants. The American Cancer Society's Epidemiology Research Program invited men and women between the ages of 30 and 65 years who had no personal history of cancer to join this historic research study. The ultimate goal was to enroll at least 300,000 adults from various racial and ethnic backgrounds from across the United States and Puerto Rico.

The successful completion of this enrollment was built on the partnership of Society staff and over 30,000 volunteers with enrollments being conducted at over 800 Relay For Life events, 100 Society events including Making Strides Against Breast Cancer and over 2,000 corporate, hospital and community partner hosted events. CPS-3 has participants from all over the United States and Puerto Rico with average age at enrollment of 47 years.

Now that we have completed the initial recruitment of our participants, we will be shifting our efforts to the next phase of the study called follow-up, which includes our first follow-up survey for the entire population. In addition to our follow-up survey, a small group of CPS-3 participants will be invited to participate in one of two sub-studies that we will be conducting this year on diet, physical activity, light and sleep patterns. These sub-studies are an essential component to maintaining the highest scientific standards in our study.

For more information about CPS-3 or for participant inquiries including change of address or participant status, please email CPS3@cancer.org or call toll-free 1-888-604-5888.